Autophosphorylation of Polo-like Kinase 4 and Its Role in Centriole Duplication

Centrosome duplication occurs once every cell cycle in a strictly controlled manner. Polo-like kinase 4 (PLK4) is a key regulator of this process whose kinase activity is essential for centriole duplication. Here, we show that PLK4 autophosphorylation of serine S305 is a consequence of kinase activa...

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Autors principals: Sillibourne, James E., Tack, Frederik, Vloemans, Nele, Boeckx, An, Thambirajah, Sathiesan, Bonnet, Pascal, Ramaekers, Frans C.S., Bornens, Michel, Grand-Perret, Thierry
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Cell Biology 2010
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2820420/
https://ncbi.nlm.nih.gov/pubmed/20032307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E09-06-0505
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