Chymase Inhibition Prevents Fibronectin and Myofibrillar Loss and Improves Cardiomyocyte Function and LV Torsion Angle in Dogs with Isolated Mitral Regurgitation

BACKGROUND: The LV dilatation of isolated mitral regurgitation (MR) is associated with an increase in chymase and a decrease in interstitial collagen and extracellular matrix (ECM). In addition to pro-fibrotic effects, chymase has significant antifibrotic actions because it activates matrix metallop...

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Autori principali: Pat, Betty, Chen, Yuanwen, Killingsworth, Cheryl, Gladden, James D, Shi, Ke, Zheng, Junying, Powell, Pamela C, Walcott, Greg, Ahmed, Mustafa I, Gupta, Himanshu, Desai, Ravi, Wei, Chih-Chang, Hase, Naoki, Kobayashi, Tsunefumi, Sabri, Abdelkarim, Granzier, Henk, Denney, Thomas, Tillson, Michael, Dillon, A Ray, Husain, Ahsan, Dell’Italia, Louis J
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3092363/
https://ncbi.nlm.nih.gov/pubmed/20876440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.109.921619
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