CDK Inhibitors Roscovitine and CR8 Trigger Mcl-1 Down-Regulation and Apoptotic Cell Death in Neuroblastoma Cells

Neuroblastoma (NB), the most frequent extracranial solid tumor of children accounting for nearly 15% of all childhood cancer mortality, displays overexpression of antiapoptotic Bcl-2 and Mcl-1 in aggressive forms of the disease. The clinical phase 2 drug roscovitine (CYC202, seliciclib), a relativel...

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Bibliographic Details
Main Authors: Bettayeb, Karima, Baunbæk, Dianne, Delehouze, Claire, Loaëc, Nadège, Hole, Alison J., Baumli, Sonja, Endicott, Jane A., Douc-Rasy, Setha, Bénard, Jean, Oumata, Nassima, Galons, Hervé, Meijer, Laurent
Format: Artigo
Language:Inglês
Published: SAGE Publications 2010
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3092200/
https://ncbi.nlm.nih.gov/pubmed/21779453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1947601910369817
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