Phosphorylated AKT Expression is Associated with PIK3CA Mutation, Low Stage and Favorable Outcome in 717 Colorectal Cancers

BACKGROUND: AKT (AKT1, AKT2, and AKT3) is a downstream effector of phosphatidylinositide-3-kinase (PI3K) and plays crucial roles in protein synthesis, cellular metabolism, survival, and proliferation. The PI3K/AKT pathway is commonly activated in human cancers and recognized as a potential target fo...

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Autores principales: Baba, Yoshifumi, Nosho, Katsuhiko, Shima, Kaori, Hayashi, Marika, Meyerhardt, Jeffrey A., Chan, Andrew T., Giovannucci, Edward, Fuchs, Charles S., Ogino, Shuji
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3092033/
https://ncbi.nlm.nih.gov/pubmed/21425139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.25630
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