MGMT promoter methylation, loss of expression and prognosis in 855 colorectal cancers

OBJECTIVE: O(6)-methylguanine-DNA methyltransferase (MG MT) is a DNA repair enzyme. MGMT promoter hypermethylation and epigenetic silencing often occur as early events in carcinogenesis. However, prognostic significance of MGMT alterations in colorectal cancer remains uncertain. METHODS: Utilizing a...

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Detalhes bibliográficos
Main Authors: Shima, Kaori, Morikawa, Teppei, Baba, Yoshifumi, Nosho, Katsuhiko, Suzuki, Maiko, Yamauchi, Mai, Hayashi, Marika, Giovannucci, Edward, Fuchs, Charles S., Ogino, Shuji
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3278857/
https://ncbi.nlm.nih.gov/pubmed/21140203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10552-010-9698-z
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