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MGMT promoter methylation, loss of expression and prognosis in 855 colorectal cancers
OBJECTIVE: O(6)-methylguanine-DNA methyltransferase (MG MT) is a DNA repair enzyme. MGMT promoter hypermethylation and epigenetic silencing often occur as early events in carcinogenesis. However, prognostic significance of MGMT alterations in colorectal cancer remains uncertain. METHODS: Utilizing a...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3278857/ https://ncbi.nlm.nih.gov/pubmed/21140203 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10552-010-9698-z |
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