Hypomethylation of the IGF2 DMR in Colorectal Tumors, Detected by Bisulfite Pyrosequencing, is Associated with Poor Prognosis

BACKGROUND & AIMS: The insulin-like growth factor 2 (IGF2) gene is normally imprinted. Constitutive loss of imprinting (LOI) of IGF2 has been associated with increased risks of colon cancer and adenoma, indicating its role in carcinogenesis. The conventional LOI assay relies on a germline polymo...

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Bibliografski detalji
Glavni autori: Baba, Yoshifumi, Nosho, Katsuhiko, Shima, Kaori, Huttenhower, Curtis, Tanaka, Noriko, Hazra, Aditi, Giovannucci, Edward L., Fuchs, Charles S., Ogino, Shuji
Format: Artigo
Jezik:Inglês
Izdano: 2010
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2995815/
https://ncbi.nlm.nih.gov/pubmed/20682317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2010.07.050
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