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Phosphorylated AKT Expression is Associated with PIK3CA Mutation, Low Stage and Favorable Outcome in 717 Colorectal Cancers
BACKGROUND: AKT (AKT1, AKT2, and AKT3) is a downstream effector of phosphatidylinositide-3-kinase (PI3K) and plays crucial roles in protein synthesis, cellular metabolism, survival, and proliferation. The PI3K/AKT pathway is commonly activated in human cancers and recognized as a potential target fo...
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| Autori principali: | , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3092033/ https://ncbi.nlm.nih.gov/pubmed/21425139 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.25630 |
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