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Single Substitution within the RKTR Motif Impairs Kinase Activity but Promotes Dimerization of RAF Kinase
The serine/threonine kinase RAF is a central component of the MAPK cascade. Regulation of RAF activity is highly complex and involves recruitment to membranes and association with Ras and scaffold proteins as well as multiple phosphorylation and dephosphorylation events. Previously, we identified by...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3091254/ https://ncbi.nlm.nih.gov/pubmed/21454547 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.194167 |
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