Astrocytic Tissue Inhibitor of Metalloproteinase-1 (TIMP-1) Promotes Oligodendrocyte Differentiation and Enhances CNS Myelination

Tissue inhibitor of metalloproteinase-1 (TIMP-1) is an extracellular protein and endogenous regulator of matrix metalloproteinases (MMPs) secreted by astrocytes in response to CNS myelin injury. We have previously reported that adult TIMP-1 knock-out (KO) mice exhibit poor myelin repair following de...

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Hlavní autoři: Moore, Craig S., Milner, Richard, Nishiyama, Akiko, Frausto, Ricardo F., Serwanski, David R., Pagarigan, Roberto R., Whitton, J. Lindsay, Miller, Robert H., Crocker, Stephen J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3090636/
https://ncbi.nlm.nih.gov/pubmed/21508247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5474-10.2011
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