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β1 integrins are required for normal CNS myelination and promote AKT-dependent myelin outgrowth

Oligodendrocytes in the central nervous system (CNS) produce myelin sheaths that insulate axons to ensure fast propagation of action potentials. β1 integrins regulate the myelination of peripheral nerves, but their function during the myelination of axonal tracts in the CNS is unclear. Here we show...

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Autors principals: Barros, Claudia S., Nguyen, Tom, Spencer, Kathryn S. R., Nishiyama, Akiko, Colognato, Holly, Müller, Ulrich
Format: Artigo
Idioma:Inglês
Publicat: Company of Biologists 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2730401/
https://ncbi.nlm.nih.gov/pubmed/19633169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.038679
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