TMEM106B gene polymorphism is associated with age at onset in granulin mutation carriers and plasma granulin protein levels

OBJECTIVE: A recent genome-wide association study for frontotemporal lobar degeneration with TAR DNA-binding protein inclusions (FTLD-TDP), identified rs1990622 (TMEM106B) as a risk factor for FTLD-TDP. In this study we tested whether rs1990622 is associated with age at onset (AAO) in granulin (GRN)...

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Main Authors: Cruchaga, Carlos, Graff, Caroline, Chiang, Huei-Hsin, Wang, Jun, Hinrichs, Anthony L., Spiegel, Noah, Bertelsen, Sarah, Mayo, Kevin, Norton, Joanne B., Morris, John C., Goate, Alison
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3090529/
https://ncbi.nlm.nih.gov/pubmed/21220649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/archneurol.2010.350
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