An oxysterol biomarker for 7-dehydrocholesterol oxidation in cell/mouse models for Smith-Lemli-Opitz syndrome

The level of 7-dehydrocholesterol (7-DHC) is elevated in tissues and fluids of Smith-Lemli-Opitz syndrome (SLOS) patients due to defective 7-DHC reductase. Although over a dozen oxysterols have been identified from 7-DHC free radical oxidation in solution, oxysterol profiles in SLOS cells and tissue...

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Main Authors: Xu, Libin, Korade, Zeljka, Rosado, Dale A., Liu, Wei, Lamberson, Connor R., Porter, Ned A.
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Biochemistry and Molecular Biology 2011
Teme:
Research Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3090243/
https://ncbi.nlm.nih.gov/pubmed/21402677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M014498
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