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Conversion of 7-ketocholesterol to oxysterol metabolites by recombinant CYP27A1 and retinal pigment epithelial cells
Of the different oxygenated cholesterol metabolites, 7-ketocholesterol (7KCh) is considered a noxious oxysterol implicated in the development of certain pathologies, including those found in the eye. Here we elucidated whether sterol 27-hydroxylase cytochrome P450 27A1 (CYP27A1) is involved in elim...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
The American Society for Biochemistry and Molecular Biology
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3090233/ https://ncbi.nlm.nih.gov/pubmed/21411718 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M014217 |
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