Conversion of 7-ketocholesterol to oxysterol metabolites by recombinant CYP27A1 and retinal pigment epithelial cells

Of the different oxygenated cholesterol metabolites, 7-ketocholesterol (7KCh) is considered a noxious oxy­sterol implicated in the development of certain pathologies, including those found in the eye. Here we elucidated whether sterol 27-hydroxylase cytochrome P450 27A1 (CYP27A1) is involved in elim...

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Bibliographische Detailangaben
Hauptverfasser: Heo, Gun-Young, Bederman, Ilya, Mast, Natalia, Liao, Wei-Li, Turko, Illarion V., Pikuleva, Irina A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Biochemistry and Molecular Biology 2011
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3090233/
https://ncbi.nlm.nih.gov/pubmed/21411718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M014217
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