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N,N′-Alkane-diyl-bis-3-picoliniums as Nicotinic Receptor Antagonists: Inhibition of Nicotine-induced Dopamine Release and Hyperactivity

The current study evaluated a new series of N,N′-alkane-diyl-bis-3-picolinium (bAPi) analogs with C(6)–C(12) methylene linkers as nicotinic receptor (nAChR) antagonists, for nicotine-evoked [(3)H]dopamine (DA) overflow, for blood-brain barrier choline transporter affinity and for attenuation of disc...

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Bibliografiske detaljer
Main Authors: Dwoskin, Linda P., Wooters, Thomas E., Sumithran, Sangeetha P., Siripurapu, Kiran B., Joyce, B. Matthew, Lockman, Paul R., Manda, Vamshi K., Ayers, Joshua T., Zhang, Zhenfa, Deaciuc, Agripina G., McIntosh, J. Michael, Crooks, Peter A., Bardo, Michael T.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3089982/
https://ncbi.nlm.nih.gov/pubmed/18460644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.108.136630
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