N,N′-Alkane-diyl-bis-3-picoliniums as Nicotinic Receptor Antagonists: Inhibition of Nicotine-induced Dopamine Release and Hyperactivity

The current study evaluated a new series of N,N′-alkane-diyl-bis-3-picolinium (bAPi) analogs with C(6)–C(12) methylene linkers as nicotinic receptor (nAChR) antagonists, for nicotine-evoked [(3)H]dopamine (DA) overflow, for blood-brain barrier choline transporter affinity and for attenuation of disc...

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Main Authors: Dwoskin, Linda P., Wooters, Thomas E., Sumithran, Sangeetha P., Siripurapu, Kiran B., Joyce, B. Matthew, Lockman, Paul R., Manda, Vamshi K., Ayers, Joshua T., Zhang, Zhenfa, Deaciuc, Agripina G., McIntosh, J. Michael, Crooks, Peter A., Bardo, Michael T.
Formato: Artigo
Idioma:Inglês
Publicado: 2008
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3089982/
https://ncbi.nlm.nih.gov/pubmed/18460644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.108.136630
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