Architecture of a Full-length Retroviral Integrase Monomer and Dimer, Revealed by Small Angle X-ray Scattering and Chemical Cross-linking

We determined the size and shape of full-length avian sarcoma virus (ASV) integrase (IN) monomers and dimers in solution using small angle x-ray scattering. The low resolution data obtained establish constraints for the relative arrangements of the three component domains in both forms. Domain organ...

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Autors principals: Bojja, Ravi S., Andrake, Mark D., Weigand, Steven, Merkel, George, Yarychkivska, Olya, Henderson, Adam, Kummerling, Marissa, Skalka, Anna Marie
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2011
Matèries:
Protein Structure and Folding
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3089549/
https://ncbi.nlm.nih.gov/pubmed/21454648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.212571
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