The cAMP-responsive Rap1 Guanine Nucleotide Exchange Factor, Epac, Induces Smooth Muscle Relaxation by Down-regulation of RhoA Activity

Agonist activation of the small GTPase, RhoA, and its effector Rho kinase leads to down-regulation of smooth muscle (SM) myosin light chain phosphatase activity, an increase in myosin light chain (RLC(20)) phosphorylation and force. Cyclic nucleotides can reverse this process. We report a new mechan...

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Detalles Bibliográficos
Autores principales: Zieba, Bartosz J., Artamonov, Mykhaylo V., Jin, Li, Momotani, Ko, Ho, Ruoya, Franke, Aaron S., Neppl, Ronald L., Stevenson, Andra S., Khromov, Alexander S., Chrzanowska-Wodnicka, Magdalena, Somlyo, Avril V.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Materias:
Signal Transduction
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3089510/
https://ncbi.nlm.nih.gov/pubmed/21454546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.205062
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