Cellular FLICE-inhibitory Protein (cFLIP) Isoforms Block CD95- and TRAIL Death Receptor-induced Gene Induction Irrespective of Processing of Caspase-8 or cFLIP in the Death-inducing Signaling Complex

Death receptors (DRs) induce apoptosis but also stimulate proinflammatory “non-apoptotic” signaling (e.g. NF-κB and mitogen-activated protein kinase (MAPK) activation) and inhibit distinct steps of DR-activated maturation of procaspase-8. To examine whether isoforms of cellular FLIP (cFLIP) or its c...

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Autori principali: Kavuri, Shyam M., Geserick, Peter, Berg, Daniela, Dimitrova, Diana Panayotova, Feoktistova, Maria, Siegmund, Daniela, Gollnick, Harald, Neumann, Manfred, Wajant, Harald, Leverkus, Martin
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2011
Soggetti:
Signal Transduction
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3089506/
https://ncbi.nlm.nih.gov/pubmed/21454681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.148585
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