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AS160 Phosphotyrosine-binding Domain Constructs Inhibit Insulin-stimulated GLUT4 Vesicle Fusion with the Plasma Membrane

AS160 (TBC1D4) is a known Akt substrate that is phosphorylated downstream of insulin action and that leads to regulated traffic of GLUT4. As GLUT4 vesicle fusion with the plasma membrane is a highly regulated step in GLUT4 traffic, we investigated whether AS160 and 14-3-3 interactions are involved i...

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Main Authors: Koumanov, Françoise, Richardson, Judith D., Murrow, Beverley A., Holman, Geoffrey D.
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2011
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3089500/
https://ncbi.nlm.nih.gov/pubmed/21454690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.226092
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