Influence of C-5 substituted cytosine and related nucleoside analogs on the formation of benzo[a]pyrene diol epoxide-dG adducts at CG base pairs of DNA

Endogenous 5-methylcytosine ((Me)C) residues are found at all CG dinucleotides of the p53 tumor suppressor gene, including the mutational ‘hotspots’ for smoking induced lung cancer. (Me)C enhances the reactivity of its base paired guanine towards carcinogenic diolepoxide metabolites of polycyclic ar...

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Detaylı Bibliyografya
Asıl Yazarlar: Guza, Rebecca, Kotandeniya, Delshanee, Murphy, Kristopher, Dissanayake, Thakshila, Lin, Chen, Giambasu, George Madalin, Lad, Rahul R., Wojciechowski, Filip, Amin, Shantu, Sturla, Shana J., Hudson, Robert H.E., York, Darrin M., Jankowiak, Ryszard, Jones, Roger, Tretyakova, Natalia Y.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2011
Konular:
Synthetic Biology and Chemistry
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3089471/
https://ncbi.nlm.nih.gov/pubmed/21245046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq1341
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