Influence of C-5 substituted cytosine and related nucleoside analogs on the formation of benzo[a]pyrene diol epoxide-dG adducts at CG base pairs of DNA

Endogenous 5-methylcytosine ((Me)C) residues are found at all CG dinucleotides of the p53 tumor suppressor gene, including the mutational ‘hotspots’ for smoking induced lung cancer. (Me)C enhances the reactivity of its base paired guanine towards carcinogenic diolepoxide metabolites of polycyclic ar...

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Main Authors: Guza, Rebecca, Kotandeniya, Delshanee, Murphy, Kristopher, Dissanayake, Thakshila, Lin, Chen, Giambasu, George Madalin, Lad, Rahul R., Wojciechowski, Filip, Amin, Shantu, Sturla, Shana J., Hudson, Robert H.E., York, Darrin M., Jankowiak, Ryszard, Jones, Roger, Tretyakova, Natalia Y.
格式: Artigo
語言:Inglês
出版: Oxford University Press 2011
主題:
Synthetic Biology and Chemistry
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3089471/
https://ncbi.nlm.nih.gov/pubmed/21245046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq1341
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