Human 2′-phosphodiesterase localizes to the mitochondrial matrix with a putative function in mitochondrial RNA turnover

The vertebrate 2-5A system is part of the innate immune system and central to cellular antiviral defense. Upon activation by viral double-stranded RNA, 5′-triphosphorylated, 2′–5′-linked oligoadenylate polyribonucleotides (2-5As) are synthesized by one of several 2′–5′-oligoadenylate synthetases. Th...

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Autors principals: Poulsen, Jesper Buchhave, Andersen, Kasper Røjkjær, Kjær, Karina Hansen, Durand, Fiona, Faou, Pierre, Vestergaard, Anna Lindeløv, Talbo, Gert Hoy, Hoogenraad, Nick, Brodersen, Ditlev Egeskov, Justesen, Just, Martensen, Pia Møller
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2011
Matèries:
Nucleic Acid Enzymes
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3089451/
https://ncbi.nlm.nih.gov/pubmed/21245038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq1282
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