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The activity and selectivity of fission yeast Pop2p are affected by a high affinity for Zn(2+) and Mn(2+) in the active site
In eukaryotic organisms, initiation of mRNA turnover is controlled by progressive shortening of the poly-A tail, a process involving the mega-Dalton Ccr4-Not complex and its two associated 3′-5′ exonucleases, Ccr4p and Pop2p (Caf1p). RNA degradation by the 3′-5′ DEDDh exonuclease, Pop2p, is governed...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Cold Spring Harbor Laboratory Press
2009
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2673079/ https://ncbi.nlm.nih.gov/pubmed/19307292 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.1489409 |
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