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Synthesis, Structure-Affinity Relationships and Modeling of AMDA Analogs at 5-HT(2A) and H(1) Receptors: Structural Factors Contributing to Selectivity
Histamine H(1) and serotonin 5-HT(2A) receptors present in the CNS have been implicated in various neuropsychiatric disorders. 9-Aminomethyl-9,10-dihydroanthracene (AMDA), a conformationally constrained diarylalkyl amine derivative, has affinity for both of these receptors. A structure-affinity rela...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3088504/ https://ncbi.nlm.nih.gov/pubmed/19700330 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2009.08.016 |
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