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9-Aminomethyl-9,10-dihydroanthracene (AMDA) Analogs as Structural Probes for Steric Tolerance in 5-HT(2A) and H(1) Receptor Binding Sites

Synthesis, radioligand binding and molecular modeling studies of several 9-aminomethyl-9,10-dihydroanthracene (AMDA) analogs were carried out to determine the extent of the steric tolerance associated with expansion of the tricyclic ring system and amine substitution at 5-HT(2A) and H(1) receptors....

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Detalhes bibliográficos
Main Authors: Shah, Jitesh R., Mosier, Philip D., Peddi, Srinivas, Roth, Bryan L., Westkaemper, Richard B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3252747/
https://ncbi.nlm.nih.gov/pubmed/20045641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.12.064
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