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Novel K540N Mutation in Plasmodium falciparum Dihydropteroate Synthetase Confers a Lower Level of Sulfa Drug Resistance than Does a K540E Mutation
Sulfadoxine (SDX) and sulfamethoxazole (SMX) each inhibit the Plasmodium falciparum dihydropteroate synthetase (PfDHPS), and certain point mutations in this enzyme yield the drug-resistant parasite. Using a simple Escherichia coli model system, we describe here the effect of the recently reported no...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3088265/ https://ncbi.nlm.nih.gov/pubmed/21343464 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01394-10 |
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