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Inhibition of Plasmodium falciparum dihydropteroate synthetase and growth in vitro by sulfa drugs.

The Michaelis-Menten inhibitory constants (Kis) and the concentrations required for 50% inhibition of the Plasmodium falciparum dihydropteroate synthetase were determined for six sulfa drugs. These drugs inhibited the in vitro growth of P. falciparum (50% lethal concentration) at concentrations of 3...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Zhang, Y, Meshnick, S R
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 1991
Subjects:
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC244989/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2024960/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.35.2.267
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