Quantitative Structure-Activity Relationship Studies of a Series of Sulfa Drugs as Inhibitors of Pneumocystis carinii Dihydropteroate Synthetase

Sulfone and sulfanilamide sulfa drugs have been shown to inhibit dihydropteroate synthetase (DHPS) isolated from Pneumocystis carinii. In order to develop a pharmacophoric model for this inhibition, quantitative structure-activity relationships (QSAR) for sulfa drugs active against DHPS have been st...

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Dades bibliogràfiques

Publicat a:	Antimicrob Agents Chemother
Autors principals:	Johnson, Theresa, Khan, Ikhlas A., Avery, Mitchell A., Grant, Juliana, Meshnick, Steven R.
Format:	Artigo
Idioma:	Inglês
Publicat:	American Society for Microbiology (ASM) 1998
Matèries:	Mechanisms of Action: Physiological Effects
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC105621/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9624493/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.42.6.1454
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