Quantitative Structure-Activity Relationship Studies of a Series of Sulfa Drugs as Inhibitors of Pneumocystis carinii Dihydropteroate Synthetase

Sulfone and sulfanilamide sulfa drugs have been shown to inhibit dihydropteroate synthetase (DHPS) isolated from Pneumocystis carinii. In order to develop a pharmacophoric model for this inhibition, quantitative structure-activity relationships (QSAR) for sulfa drugs active against DHPS have been st...

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Опубликовано в::	Antimicrob Agents Chemother
Главные авторы:	Johnson, Theresa, Khan, Ikhlas A., Avery, Mitchell A., Grant, Juliana, Meshnick, Steven R.
Формат:	Artigo
Язык:	Inglês
Опубликовано:	American Society for Microbiology (ASM) 1998
Предметы:	Mechanisms of Action: Physiological Effects
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC105621/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9624493/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.42.6.1454
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