Structural Basis For Antigenic Peptide Precursor Processing by the Endoplasmic Reticulum Aminopeptidase ERAP1

ERAP1 trims antigen precursors to fit into MHC class I proteins. To perform this function, ERAP1 has unique substrate preferences, trimming long peptides while sparing shorter ones. To identify the structural basis for ERAP1's unusual properties, we determined the X-ray crystal structure of hum...

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Main Authors: Nguyen, Tina T., Chang, Shih-Chung, Evnouchidou, Irini, York, Ian A., Zikos, Christos, Rock, Kenneth L., Goldberg, Alfred L., Stratikos, Efstratios, Stern, Lawrence J.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2011
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3087843/
https://ncbi.nlm.nih.gov/pubmed/21478864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2021
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