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Crystallization and preliminary diffraction analysis of the CAL PDZ domain in complex with a selective peptide inhibitor

Cystic fibrosis (CF) is associated with loss-of-function mutations in the CF transmembrane conductance regulator (CFTR), which regulates epithelial fluid and ion homeostasis. The CFTR cytoplasmic C-terminus interacts with a number of PDZ (PSD-95/Dlg/ZO-1) proteins that modulate its intracellular tra...

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Detalhes bibliográficos
Main Authors: Amacher, Jeanine F., Cushing, Patrick R., Weiner, Joshua A., Madden, Dean R.
Formato: Artigo
Idioma:Inglês
Publicado em: International Union of Crystallography 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3087650/
https://ncbi.nlm.nih.gov/pubmed/21543871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309111009985
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