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Structures of C3b in Complex with Factors B and D Give Insight into Complement Convertase Formation

Activation of the complement cascade induces inflammatory responses and marks cells for immune clearance. In the central complement-amplification step, a complex consisting of surface-bound C3b and factor B is cleaved by factor D to generate active convertases on targeted surfaces. We present crysta...

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Detalhes bibliográficos
Main Authors: Forneris, Federico, Ricklin, Daniel, Wu, Jin, Tzekou, Apostolia, Wallace, Rachel S., Lambris, John D., Gros, Piet
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3087196/
https://ncbi.nlm.nih.gov/pubmed/21205667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1195821
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