Structural and functional implications of the complement convertase stabilized by a staphylococcal inhibitor

Activation of the complement system generates potent chemoattractants and opsonizes cells for immune clearance. Short-lived protease complexes cleave complement component C3 into anaphylatoxin C3a and opsonin C3b. Here we report the crystal structure of the C3 convertase formed by C3b and the protea...

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Main Authors: Rooijakkers, Suzan H M, Wu, Jin, Ruyken, Maartje, van Domselaar, Robert, Planken, Karel L, Tzekou, Apostolia, Ricklin, Daniel, Lambris, John D, Janssen, Bert J C, van Strijp, Jos A G, Gros, Piet
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2729104/
https://ncbi.nlm.nih.gov/pubmed/19503103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1756
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