bPiDI: a novel selective α6β2* nicotinic receptor antagonist and preclinical candidate treatment for nicotine abuse

BACKGROUND AND PURPOSE: Nicotinic acetylcholine receptors (nAChRs) containing α6β2 subunits expressed by dopamine neurons regulate nicotine-evoked dopamine release. Previous results show that the α6β2* nAChR antagonist, N,N′-dodecane-1,12-diyl-bis-3-picolinium dibromide (bPiDDB) inhibits nicotine-ev...

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Detalhes bibliográficos
Main Authors: Wooters, Thomas E, Smith, Andrew M, Pivavarchyk, Marharyta, Siripurapu, Kiran B, McIntosh, J Michael, Zhang, Zhenfa, Crooks, Peter A, Bardo, Michael T, Dwoskin, Linda P
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2011
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3087136/
https://ncbi.nlm.nih.gov/pubmed/21232049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2011.01220.x
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