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WNT-3A modulates articular chondrocyte phenotype by activating both canonical and noncanonical pathways
Activation and disruption of Wnt/β-catenin signaling both result in cartilage breakdown via unknown mechanisms. Here we show that both WNT-3A and the Wnt inhibitor DKK1 induced de-differentiation of human articular chondrocytes through simultaneous activation of β-catenin–dependent and independent r...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3087013/ https://ncbi.nlm.nih.gov/pubmed/21536751 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201011051 |
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