Agrin mediates chondrocyte homeostasis and requires both LRP4 and α-dystroglycan to enhance cartilage formation in vitro and in vivo

OBJECTIVES: Osteoarthritis (OA) is a leading cause of disability for which there is no cure. The identification of molecules supporting cartilage homeostasis and regeneration is therefore a major pursuit in musculoskeletal medicine. Agrin is a heparan sulfate proteoglycan which, through binding to l...

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Detalhes bibliográficos
Publicado no:Ann Rheum Dis
Main Authors: Eldridge, Suzanne, Nalesso, Giovanna, Ismail, Habib, Vicente-Greco, Karin, Kabouridis, Panos, Ramachandran, Manoj, Niemeier, Andreas, Herz, Joachim, Pitzalis, Costantino, Perretti, Mauro, Dell'Accio, Francesco
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2016
Assuntos:
Basic and Translational Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4760904/
https://ncbi.nlm.nih.gov/pubmed/26290588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2015-207316
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