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WNT16 antagonises excessive canonical WNT activation and protects cartilage in osteoarthritis

OBJECTIVE: Both excessive and insufficient activation of WNT signalling results in cartilage breakdown and osteoarthritis. WNT16 is upregulated in the articular cartilage following injury and in osteoarthritis. Here, we investigate the function of WNT16 in osteoarthritis and the downstream molecular...

詳細記述

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書誌詳細
出版年:Ann Rheum Dis
主要な著者: Nalesso, Giovanna, Thomas, Bethan Lynne, Sherwood, Joanna Claire, Yu, Jing, Addimanda, Olga, Eldridge, Suzanne Elizabeth, Thorup, Anne-Sophie, Dale, Leslie, Schett, Georg, Zwerina, Jochen, Eltawil, Noha, Pitzalis, Costantino, Dell'Accio, Francesco
フォーマット: Artigo
言語:Inglês
出版事項: BMJ Publishing Group 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5264226/
https://ncbi.nlm.nih.gov/pubmed/27147711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2015-208577
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