WNT16 antagonises excessive canonical WNT activation and protects cartilage in osteoarthritis

OBJECTIVE: Both excessive and insufficient activation of WNT signalling results in cartilage breakdown and osteoarthritis. WNT16 is upregulated in the articular cartilage following injury and in osteoarthritis. Here, we investigate the function of WNT16 in osteoarthritis and the downstream molecular...

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Detalles Bibliográficos
Publicado en:Ann Rheum Dis
Main Authors: Nalesso, Giovanna, Thomas, Bethan Lynne, Sherwood, Joanna Claire, Yu, Jing, Addimanda, Olga, Eldridge, Suzanne Elizabeth, Thorup, Anne-Sophie, Dale, Leslie, Schett, Georg, Zwerina, Jochen, Eltawil, Noha, Pitzalis, Costantino, Dell'Accio, Francesco
Formato: Artigo
Idioma:Inglês
Publicado: BMJ Publishing Group 2017
Assuntos:
Basic and Translational Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5264226/
https://ncbi.nlm.nih.gov/pubmed/27147711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2015-208577
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