WNT-3A modulates articular chondrocyte phenotype by activating both canonical and noncanonical pathways

Activation and disruption of Wnt/β-catenin signaling both result in cartilage breakdown via unknown mechanisms. Here we show that both WNT-3A and the Wnt inhibitor DKK1 induced de-differentiation of human articular chondrocytes through simultaneous activation of β-catenin–dependent and independent r...

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Bibliographische Detailangaben
Hauptverfasser: Nalesso, Giovanna, Sherwood, Joanna, Bertrand, Jessica, Pap, Thomas, Ramachandran, Manoj, De Bari, Cosimo, Pitzalis, Costantino, Dell'Accio, Francesco
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2011
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3087013/
https://ncbi.nlm.nih.gov/pubmed/21536751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201011051
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