ACE2 Deficiency in Whole Body or Bone Marrow-Derived Cells Increases Atherosclerosis in LDL Receptor −/− Mice

OBJECTIVE: The renin-angiotensin system (RAS) contributes to atherosclerotic lesion formation. Angiotensin converting enzyme 2 (ACE2) catabolizes angiotensin II (AngII) to angiotensin-(1–7) (Ang-(1–7)) to limit effects of the RAS. The purpose of this study was to define the role of ACE2 in atheroscl...

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Main Authors: Thatcher, Sean E., Zhang, Xuan, Howatt, Deborah A., Lu, Hong, Gurley, Susan B., Daugherty, Alan, Cassis, Lisa A.
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3086633/
https://ncbi.nlm.nih.gov/pubmed/21252069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.110.221614
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