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S-nitrosylation from GSNOR Deficiency Impairs DNA Repair and Promotes Hepatocarcinogenesis

Human hepatocellular carcinoma is associated with elevated expression of inducible nitric oxide synthase (iNOS), but the role of nitric oxide in the pathogenesis of hepatocellular carcinoma remains unknown. Here we show that the abundance and activity of S-nitrosoglutathione reductase (GSNOR), a pro...

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Hlavní autoři: Wei, Wei, Li, Bin, Hanes, Martha A., Kakar, Sanjay, Chen, Xin, Liu, Limin
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3085984/
https://ncbi.nlm.nih.gov/pubmed/20371487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3000328
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