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S-nitrosylation from GSNOR Deficiency Impairs DNA Repair and Promotes Hepatocarcinogenesis

Human hepatocellular carcinoma is associated with elevated expression of inducible nitric oxide synthase (iNOS), but the role of nitric oxide in the pathogenesis of hepatocellular carcinoma remains unknown. Here we show that the abundance and activity of S-nitrosoglutathione reductase (GSNOR), a pro...

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Bibliografiske detaljer
Main Authors: Wei, Wei, Li, Bin, Hanes, Martha A., Kakar, Sanjay, Chen, Xin, Liu, Limin
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3085984/
https://ncbi.nlm.nih.gov/pubmed/20371487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3000328
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