Nonstructural Protein 5A Impairs DNA Damage Repair: Implications for Hepatitis C Virus-Mediated Hepatocarcinogenesis

RAD51-associated protein 1 (RAD51AP1) is a member of the multiprotein complexes postulated to carry out RAD51-mediated homologous recombination and DNA repair in mammalian cells. In the present study, we showed that hepatitis C virus (HCV) NS5A directly bound RAD51AP1 and increased the protein level...

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Bibliographic Details
Published in:J Virol
Main Authors: Nguyen, Tram T. T., Park, Eun-Mee, Lim, Yun-Sook, Hwang, Soon B.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2018
Subjects:
Virus-Cell Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5952158/
https://ncbi.nlm.nih.gov/pubmed/29563287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00178-18
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