Hsp90 Regulates NADPH Oxidase Activity and Is Necessary for Superoxide but Not Hydrogen Peroxide Production

The goal of this study was to identify whether heat-shock protein 90 (Hsp90) regulates the production of superoxide and other reactive oxygen species from the NADPH oxidases (Nox). We found that pharmacological and genetic inhibition of Hsp90 directly reduced Nox5-derived superoxide without secondar...

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Bibliographic Details
Main Authors: Chen, Feng, Pandey, Deepesh, Chadli, Ahmed, Catravas, John D., Chen, Teng, Fulton, David J.R.
Format: Artigo
Language:Inglês
Published: Mary Ann Liebert, Inc. 2011
Subjects:
Original Research Communications
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3085945/
https://ncbi.nlm.nih.gov/pubmed/21194376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2010.3669
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