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Physiologically Based Pharmacokinetic Model of Amphotericin B Disposition in Rats Following Administration of Deoxycholate Formulation (Fungizone®): Pooled Analysis of Published Data

The time course of tissue distribution of amphotericin B (AmB) has not been sufficiently characterized despite its therapeutic importance and an apparent disconnect between plasma pharmacokinetics and clinical outcomes. The goals of this work were to develop and evaluate a physiologically based phar...

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Autors principals: Kagan, Leonid, Gershkovich, Pavel, Wasan, Kishor M., Mager, Donald E.
Format: Artigo
Idioma:Inglês
Publicat: Springer US 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3085707/
https://ncbi.nlm.nih.gov/pubmed/21431453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-011-9267-8
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