Human Xeno-autoantibodies Against a Non-human Sialic acid Serve As Novel Serum Biomarkers and Immunotherapeutics in Cancer

Human carcinomas can metabolically incorporate and present the dietary non-human sialic acid Neu5Gc, which differs from the human sialic acid N-acetylneuraminic acid (Neu5Ac) by one oxygen atom. Tumor-associated Neu5Gc can interact with low levels of circulating anti-Neu5Gc antibodies, thereby facil...

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Detalhes bibliográficos
Main Authors: Padler-Karavani, Vered, Hurtado-Ziola, Nancy, Pu, Minya, Yu, Hai, Huang, Shengshu, Muthana, Saddam, Chokhawala, Harshal A., Cao, Hongzhi, Secrest, Patrick, Friedmann-Morvinski, Dinorah, Singer, Oded, Ghaderi, Darius, Verma, Inder M., Liu, Yu-Tsueng, Messer, Karen, Chen, Xi, Varki, Ajit, Schwab, Richard
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3085609/
https://ncbi.nlm.nih.gov/pubmed/21505105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-4102
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