Evidence for a novel human-specific xeno-auto-antibody response against vascular endothelium

Humans are genetically unable to synthesize the common mammalian sialic acid N-glycolylneuraminic acid (Neu5Gc). However, Neu5Gc can be metabolically incorporated and covalently expressed on cultured human cell surfaces. Meanwhile, humans express varying and sometimes high titers of polyclonal anti-...

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Detalhes bibliográficos
Main Authors: Pham, Tho, Gregg, Christopher J., Karp, Felix, Chow, Renee, Padler-Karavani, Vered, Cao, Hongzhi, Chen, Xi, Witztum, Joseph L., Varki, Nissi M., Varki, Ajit
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2009
Assuntos:
Vascular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2792214/
https://ncbi.nlm.nih.gov/pubmed/19828701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-05-220400
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