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LC-MS analysis of polyclonal human anti-Neu5Gc Xeno-autoantibodies IgG subclass and partial sequence using multi-step IVIG affinity purification and multi-enzymatic digestion

Human polyclonal IgG antibodies directly against the non-human sialic acid N-glycolylneuraminic acid (Neu5Gc) are potential biomarkers and mechanistic contributors to cancer and other diseases associated with chronic inflammation. Using a sialoglycan microarray, we screened the binding pattern of su...

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Detalhes bibliográficos
Main Authors: Lu, Qiaozhen, Padler-Karavani, Vered, Yu, Hai, Chen, Xi, Wu, Shiaw-Lin, Varki, Ajit, Hancock, William S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4142218/
https://ncbi.nlm.nih.gov/pubmed/22390546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ac2030893
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