Polo-like kinase-1 as a novel target in neoplastic mast cells: demonstration of growth-inhibitory effects of small interfering RNA and the Polo-like kinase-1 targeting drug BI 2536

BACKGROUND: In advanced systemic mastocytosis the response of neoplastic mast cells to conventional drugs is poor and the prognosis is bad. Current research is, therefore, attempting to identify novel drug targets in neoplastic mast cells. Polo-like kinase-1 is a serine/threonine kinase that plays a...

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Detalhes bibliográficos
Main Authors: Peter, Barbara, Gleixner, Karoline V., Cerny-Reiterer, Sabine, Herrmann, Harald, Winter, Viviane, Hadzijusufovic, Emir, Ferenc, Veronika, Schuch, Karina, Mirkina, Irina, Horny, Hans-Peter, Pickl, Winfried F., Müllauer, Leonhard, Willmann, Michael, Valent, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: Ferrata Storti Foundation 2011
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3084913/
https://ncbi.nlm.nih.gov/pubmed/21242189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2010.031328
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