Polo-like kinase-1 as a novel target in neoplastic mast cells: demonstration of growth-inhibitory effects of small interfering RNA and the Polo-like kinase-1 targeting drug BI 2536

BACKGROUND: In advanced systemic mastocytosis the response of neoplastic mast cells to conventional drugs is poor and the prognosis is bad. Current research is, therefore, attempting to identify novel drug targets in neoplastic mast cells. Polo-like kinase-1 is a serine/threonine kinase that plays a...

Полное описание

Сохранить в:
Библиографические подробности
Главные авторы: Peter, Barbara, Gleixner, Karoline V., Cerny-Reiterer, Sabine, Herrmann, Harald, Winter, Viviane, Hadzijusufovic, Emir, Ferenc, Veronika, Schuch, Karina, Mirkina, Irina, Horny, Hans-Peter, Pickl, Winfried F., Müllauer, Leonhard, Willmann, Michael, Valent, Peter
Формат: Artigo
Язык:Inglês
Опубликовано: Ferrata Storti Foundation 2011
Предметы:
Original Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3084913/
https://ncbi.nlm.nih.gov/pubmed/21242189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2010.031328
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы