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Small interfering RNA knocks down the molecular target of alendronate, farnesyl pyrophosphate synthase, in osteoclast and osteoblast cultures

Farnesyl pyrophosphate synthase (FPPS), an enzyme in the mevalonate pathway, is the inhibition target of alendronate, a potent FDA-approved nitrogen-containing bisphosphonate (N-BP) drug, at the molecular level. Alendronate not only inhibits osteoclasts, but also has been reported to positively affe...

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Sonraí Bibleagrafaíochta
Main Authors: Wang, Yuwei, Panasiuk, Alexandra, Grainger, David W.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2011
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3084905/
https://ncbi.nlm.nih.gov/pubmed/21186792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp100374n
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