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Small interfering RNA knocks down the molecular target of alendronate, farnesyl pyrophosphate synthase, in osteoclast and osteoblast cultures

Farnesyl pyrophosphate synthase (FPPS), an enzyme in the mevalonate pathway, is the inhibition target of alendronate, a potent FDA-approved nitrogen-containing bisphosphonate (N-BP) drug, at the molecular level. Alendronate not only inhibits osteoclasts, but also has been reported to positively affe...

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Библиографические подробности
Главные авторы: Wang, Yuwei, Panasiuk, Alexandra, Grainger, David W.
Формат: Artigo
Язык:Inglês
Опубликовано: 2011
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3084905/
https://ncbi.nlm.nih.gov/pubmed/21186792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp100374n
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